Deep Cleansing Moisturizing Face Wash

  • Deep Cleansing Moisturizing Face Wash
  • video
  • MANSI
  • China
  • 3~5days
  • 5000prices
Product Name: MANSI Deep Cleansing Moisturizing Face Wash Product Specification: 120g Skin Type: All Skin Types Product Features: Amino Acid Cleanser, Gentle & Mild, with Rich Foam. Leaves skin fresh and non-stripped. Formulated with multiple active ingredients for a combined cleansing & caring experience. Key Ingredients: DH071 Oil-Control Complex CQ-006 DF402 Oat β-Glucan MG-60

About Us


MANSI is a subsidiary of BIOBASE Group which is a cosmetics manufacturer since the year of 1997 with more than 3000 employees and 24 factories

Oversea branches in USA,Dubai,Singapore,India,Myanmar,Kazakhstan


Daily Output

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Our Service

ONE STOP OEM&ODM SERVICE

Formula Design,Free Sample,Label and Packaging Design,Certificates Rregistration

Product Specification

Brand:MANSI

Product efficacy: Amino Acid Cleanser, Gentle & Mild, with Rich Foam. Leaves skin fresh and non-stripped. Formulated with multiple active ingredients for a combined cleansing & caring experience.

120g/bottle

Main Ingredient

Key Ingredient — DH071 Oil-Control Complex CQ-006

Patent: Authorized patent covers the unique extraction process and synergistic effect of the optimal formula ratio.

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Composition: Forsythia Suspensa, Anemarrhena Asphodeloides and Pueraria Lobata

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Modern Research: Forsythia Suspensa, Anemarrhena Asphodeloides and Pueraria Lobata are reported to regulate sebum secretion, provide antioxidant benefits, improve microcirculation, and exhibit antibacterial and anti-inflammatory properties.


Core Ingredient -- DF402 Oat β-Glucan

Mechanism of action of low-molecular-weight oat β-glucan in promoting keratinocyte differentiation:
  1. 1.Promotes CaSR expression;

  2. 2.Activates the CaSR-mediated p120-catenin and PLCγ1 pathways, as well as the ERK and p38 pathways;

  3. 3.When CaSR is blocked, low-molecular-weight oat β-glucan fails to promote HaCaT cell differentiation;

  4. 4.When CaSR is blocked, the ability of low-molecular-weight oat β-glucan to activate the CaSR-p120-catenin-PLCγ1 signaling pathway is abolished.


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Experimental Results: The low-molecular-weight oat β-glucan was found to effectively promote the expression of FLG and Caspase-14, and exhibited a favorable dose-response relationship even at low concentrations.


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Experimental Results:Low-molecular-weight oat β-glucan can effectively promote the expression of the differentiation marker genes Loricrin and Filaggrin in HaCaT cells, thereby achieving effective differentiation of keratinocytes.


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Immunohistochemical analysis of the dorsal skin lesion area showed that:

The expression levels of the differentiation marker proteins Loricrin and Filaggrin in the epidermal tissue of the low-molecular-weight oat β-glucan group were significantly higher than those in the model group. Low-molecular-weight oat β-glucan can effectively promote the differentiation of keratinocytes in damaged skin.


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Experimental Results:

In a low-calcium environment, low-molecular-weight oat β-glucan can induce both transient and sustained increases in intracellular calcium concentration. Thus, even when the stratum corneum barrier is damaged and extracellular calcium in the epidermis is significantly depleted, it can still raise intracellular calcium levels in keratinocytes, thereby promoting their normal differentiation.


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The rate of barrier damage recovery in mice treated with low-molecular-weight oat β-glucan was significantly accelerated, with particularly notable effects at 48 h and 72 h.


Core Ingredient -- MG-60
INCI: Maltodextrin, Hydrolyzed Starch, Aqua
Functions of MG-60:
  1. 1.Cell energizing effect

  2. 2.Cell protection effect

  3. 3.Protective effect against UV-induced cell damage

  4. 4.Anti-inflammatory effect

  5. 5.Effect on inhibiting rough skin texture


Anti-inflammatory activity — Effects on TNF-α produced by keratinocytes.

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The keratinocyte cell line was stimulated with IL-1β (1 ng/mL) in the presence of either MG-60 or glycerol. After 6 hours, the amount of TNF-α in the culture medium was measured by EIA, and cell viability was determined using the MTT assay.
★ MG-60 showed no cytotoxic effects and inhibited the production of TNF-α, one of the inflammatory cytokines.


Effects on TNF-α produced by macrophages.

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The macrophage cell line was stimulated with IFN-γ (10 IU/mL) and LPS (1 μg/mL) in the presence of either MG-60 or glycerol. After 4 hours, the amount of TNF-α in the culture medium was measured by EIA, and cell viability was determined using the MTT assay.
★ MG-60 showed no cytotoxic effects and inhibited the production of TNF-α, one of the inflammatory cytokines.


Cell energizing effect, preventing cellular dryness, and protecting cells from UV-induced damage

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Cell Energizing Effect: Evaluated using human skin fibroblasts via biochemical assay analysis.

★ At a final MG-60 concentration of 0.6%, a cell proliferation rate of 120.1% relative to the control standard was confirmed.


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Mouse fibroblast cell lines were pre-incubated in culture medium containing 1% Test Material 1, then the medium was removed and the cells were placed in an artificially dehydrated environment for 1 hour, after which the cell proliferation rate was calculated.
★ Cells are damaged when dehydrated, and MG-60 exerts a protective effect against cellular dryness.


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Human fibroblasts were cultured with 0.5% MG-60 and then irradiated with UVB at 20 mJ/cm².

Two days later, the cells were harvested and counted. ★ UV irradiation causes cell damage and reduces cell viability. MG-60 can alleviate such UV-induced

cell damage.


Inhibits skin roughness

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The inner upper arm of human subjects was photographed using a Keyence VH-7000 digital HD microscope at the designated test application sites. The sites were occluded for 2 hours with either 10% SDS aqueous solution or 10% SDS aqueous solution supplemented with MG-60 to a final concentration of 20%. After occlusion, the treated areas were observed under the microscope.
★ Combined application with MG-60 effectively alleviates skin roughness and relieves inflammation.

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Application of SDS leads to skin roughness. Co-application with MG-60 markedly inhibits this condition.

A similar inhibitory effect on skin roughness was also observed when MG-60 was applied in advance.

MANSI Product

* Skin Care (toner, lotion, cream, essence, facial mask, spray, cleansers , sunscreen, etc.)

* Body Care  (body wash, scrub,body oil,body lotionetc.)

* Hair Care  (shampoo, hair care oil, conditioner hair tonic etc.)                                                                    

* Professional Beauty Salon Chains  ( massage oil, massage cream, post-project care products, etc.)

* Special Products (eye, lips, infants, children, etc.)

* Household Chemical Products (Laundry detergent& pods, floor cleaner, kitchen degreaser, washing machine cleaner, etc.)   

* Medical Cosmetic  (Recombinant Collagen Wound Dressing,Recombinant Mussel Mucin Rerair Dressing for post-medical aesthetic repair, etc.)

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R&D TEAM

MANSI has a professional cosmetics R&D team and an independent cosmetics research and development center.

At present, the cosmetics research & development teams has more than 500 people, employs many well-known industry experts. MANSI laboratory reserves more than 5000 raw materials and more than 800 formulas. MANSI also has multiple cosmetics functional laboratories such as formula R&D  laboratories, anti-corrosion challenge laboratories, cosmetics stability inspection laboratories, packaging

material compatibility testing laboratories, cosmetics in-vitro test laboratories, human body efficacy laboratories etc.

MANSI R&D team always follows customer-centric principle with sincere and efficient service attitude. MANSI is committed to developing high-quality, cost-effective cosmetics that satisfy customers

Human Body Efficacy Experimental 


Cosmetic Efficacy Laboratories have human body efficacy evaluation, human body safety evaluation, in-vitro efficacy detection and so on with VISIA, Multi-Probe Skin Elasticity Tester (MPA580), VC20 and other professional imported equipment. The test capabilities cover human body efficacy evaluation test, consumer use test, laboratory tests, human body safety evaluation and other fields.

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Certificates

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Quality Management System Certification ISO9001 & ISO13485

Cosmetics Production Certification ISO22716

US GMPC Certification   FDA  TFDA



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