About Us
MANSI is a subsidiary of BIOBASE Group which is a cosmetics manufacturer since the year of 1997 with more than 3000 employees and 24 factories
Oversea branches in USA,Dubai,Singapore,India,Myanmar,Kazakhstan
Daily Output
Our Service
ONE STOP OEM&ODM SERVICE
Formula Design,Free Sample,Label and Packaging Design,Certificates Rregistration
Product Specification
Brand:MANSI
Product efficacy: Anti-wrinkle, moisturizing
3g, 15g, 30g
Main Ingredient
Taimeitai® RCS0167 (Trade Name)
Its INCI names are Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. Composed of two "matrikines", these peptides interact with specific receptors to activate genes involved in wound repair, regulating key processes such as fibroblast recruitment, cell proliferation, keratinocyte adhesion and anchorage, and extracellular matrix synthesis. It also exerts significant regenerative and repairing effects on age-related skin damage.
Reversing Natural Aging & Preventing Photoaging
Progerin (Premature Aging Protein)
Progerin, a mutant form of normal lamin A, is a marker of aging. Its expression increases with age, leading to accelerated skin aging.
Preventing Photoaging
Dermal Papillary Layer
UVA penetrates the dermal papillary layer and accelerates skin aging, making it a primary cause of photoaging. Therefore, protecting the dermal papillary layer is a fundamental step in preventing photoaging.
Mechanism of Action:
It repairs age-related skin damage through two complementary and synergistic pathways.
Matrikines
Specific sequences in extracellular matrix (ECM) proteins stimulate beneficial skin components such as type I and type III collagen and fibronectin. These sequences are released during ECM turnover, sending signals that trigger ECM repair. The short peptide sequences released via these mechanisms are known as "matrikines".
It reduced the activity of age-related β-galactosidase by 56%.
With advancing age, the levels of structural proteins, anchoring proteins, and adhesion proteins in the dermis significantly decline. By enhancing the expression of anchoring proteins and adhesion proteins in skin tissue, Taimetai® Peptide 3000 contributes to reversing natural skin aging.
The increased density of SLEB confirms its ability to reinforce the dermal papillary layer.
Analysis of SLEB – Improvement in SLEB thickness: Two months of use delayed photoaging by 5 years!
Improvement of the dermal fiber network structure: Reduces fragmentation of the reticular structure in the dermis and facilitates the reconstruction of dermal fibrous structures.
DF402 Oat β-Glucan
FLG and Caspase-14 are two key factors reflecting skin barrier function and serve as important targets for endogenous moisturization strategies. Severe deficiencies in their expression can lead to a significant reduction in stratum corneum NMF (natural moisturizing factors), dehydration of the stratum corneum, impaired skin barrier function, and the onset of various skin diseases. A mild decrease in their expression may reduce the water-holding capacity of the stratum corneum, causing dry skin and triggering multiple suboptimal skin conditions. The selected low-molecular-weight oat β-glucan can effectively promote the expression of FLG and Caspase-14, with an excellent dose-response relationship even at low concentrations.
Small-molecule oat β-glucan effectively increases the intracellular calcium ion concentration in keratinocytes by upregulating the expression of CaSR and activating the regulatory effects of CaSR on the PLCγ1 and p120-catenin signaling pathways, thereby promoting keratinocyte differentiation.
Repair Mechanism
Low-molecular-weight oat β-glucan increases the expression of FLG and Caspase-14 in keratinocytes, promoting the production of NMF, enhancing endogenous moisturization, and maintaining skin barrier health.
By upregulating the expression of CaSR in keratinocytes and activating the CaSR-mediated PLC-γ1/catenin pathway, low-molecular-weight oat β-glucan improves the sensitivity of keratinocytes to extracellular Ca²⁺. As a result, even when the Ca²⁺ concentration gradient is disrupted due to epidermal barrier damage, it still promotes the normal differentiation of keratinocytes, ultimately facilitating the repair of epidermal barrier damage.
Experimental results: The screened small-molecule oat β-glucan can effectively promote the expression of FLG and Caspase-14, and presents a favorable dose-effect relationship even at low concentrations.
Experimental results: Small-molecule oat β-glucan effectively promotes the expression of differentiation marker genes Loricrin and Filaggrin in HaCaT cells, thereby facilitating the effective differentiation of keratinocytes.
Immunohistochemical analysis of the dorsal lesion area revealed that the expression levels of differentiation marker proteins—keratin 18 (K18) and filaggrin—in epidermal tissues were significantly higher in the small-molecule oat β-glucan group compared to the control group. Small-molecule oat β-glucan effectively promotes the differentiation of keratinocytes in damaged skin.
Experimental results: Under low calcium concentration conditions, small-molecule oat β-glucan can induce transient and sustained increases in intracellular calcium ion concentrations. This effect persists even when the stratum corneum barrier is compromised and substantial extracellular calcium ions are lost from epidermal cells, thereby elevating intracellular calcium levels in keratinocytes and promoting their normal differentiation.
Mice in the small-molecule oat β-glucan administration group exhibited significantly accelerated recovery of barrier damage, with particularly pronounced effects at 48 and 72 hours.
D.S.B. C SP2 (Trade Name)
The INCI names are Silsesquioxane Salicylate and Methylpropanediol. Silsesquioxane Salicylate is a derivative of salicylic acid, but unlike salicylic acid itself, D.S.B. C does not cause irritation. It offers soothing and anti-allergic benefits while also scavenging free radicals, making it suitable for use in anti-aging cosmetics.
Soothe skin and reduce inflammation
The secretion level of interleukin IL-1a & IL-6 decreases with increasing concentrations of D.S.B.C.
D.S.B.C can effectively inhibit the production of three pro-inflammatory cytokines. Its efficacy is comparable to that of Hydrocortisone HC (0.1%), a commonly used anti-inflammatory control agent in research.
Control group exposed to UVB but not treated with D.S.B.C. VS 4% D.S.B.C was pretreated and then irradiated with UVB
UVB irradiation alters the structure of the epidermis and induces extensive cell death. Human Reconstructed Epidermis (HRE) after irradiation exhibits thickened and detached stratum corneum, along with numerous condensed cell nuclei. These phenomena are not observed in samples treated with D.S.B. C.
D.S.B. C results in the lowest production of malondialdehyde, an oxidation product. This indicates that silanols have an affinity with carbohydrates, the structure of salicylic acid can neutralize free radicals, and D.S.B. C is capable of scavenging free radicals.
Niacinamide
Niacinamide (also known as nicotinamide) is the amide form of nicotinic acid. It appears as a white crystalline powder, is odorless or nearly odorless, has a bitter taste, and is slightly hygroscopic.
Niacinamide acts on existing melanin to reduce its transfer to surface cells, thereby reducing excessive pigmentation.
It interferes with the signaling pathways between keratinocytes and melanocytes, reducing melanin production.
When some melanin inevitably reaches the skin surface, niacinamide accelerates skin cell turnover, promoting the shedding of melanin-containing cells.
1.Niacinamide can significantly reduce pigmentation spots and brighten the skin.
2. Niacinamide delivers remarkable and long-lasting whitening effects.
3.Nicotinamide exhibits oil-control and anti-inflammatory effects, as well as inhibitory activity against acne.
TSilic® 630WDM Water-Dispersible Silicone Microspheres
A nonionic silicone emulsion containing Polymethylsilsesquioxane, Dimethicone, and Cetyl PEG/PPG-10/1 Dimethicone.
INCI Names: Water, Polymethylsilsesquioxane, Dimethicone, Isohexadecane, Cetearyl Methicone, PEG-40 Stearate, Steareth-2, Steareth-21.
It offers a silky, dry-touch feel, excellent dispersibility and stability, skin brightening effects, and matte & soft-focus properties.
Matte & Soft-Focus Performance of TSilic® 630WDM
The silicone microspheres evenly cover the skin surface, increasing surface light refraction and matteness. Its unique matte and soft-focus properties help conceal fine lines and imperfections. Compared to products like mica powder, these silicone microspheres deliver superior matte performance.
Hamamelis Virginiana (Witch Hazel) Extract
Astringent
Hamamelis Virginiana extract regulates skin balance and sebum secretion from the inside out. With astringent and antibacterial properties, it penetrates the skin quickly, visibly tightens enlarged pores, and helps prevent blackheads and acne.
Cleansing
With unique cleansing molecules, Hamamelis Virginiana acts as a deep-cleansing ingredient. It effectively regulates and refines dilated pores, purifies them, and repairs damaged skin, leaving it smoother, brighter, and more refined.
Anti-allergic & Anti-inflammatory
Witch Hazel contains soothing agents that calm sensitive skin and balance skin metabolism. It significantly reduces malondialdehyde (MDA) levels caused by intense UV radiation, preventing UV-induced skin inflammation.
Moisturizing
Hamamelis Virginiana regulates sebum secretion and has excellent water-holding capacity, delivering notable moisturizing and hydrating effects. It promotes lymphatic and blood circulation, helping reduce morning puffiness and dark circles.
MANSI Product
* Skin Care (toner, lotion, cream, essence, facial mask, spray, cleansers , sunscreen, etc.)
* Body Care (body wash, scrub,body oil,body lotionetc.)
* Hair Care (shampoo, hair care oil, conditioner hair tonic etc.)
* Professional Beauty Salon Chains ( massage oil, massage cream, post-project care products, etc.)
* Special Products (eye, lips, infants, children, etc.)
* Household Chemical Products (Laundry detergent& pods, floor cleaner, kitchen degreaser, washing machine cleaner, etc.)
* Medical Cosmetic (Recombinant Collagen Wound Dressing,Recombinant Mussel Mucin Rerair Dressing for post-medical aesthetic repair, etc.)
R&D TEAM
MANSI has a professional cosmetics R&D team and an independent cosmetics research and development center.
At present, the cosmetics research & development teams has more than 500 people, employs many well-known industry experts. MANSI laboratory reserves more than 5000 raw materials and more than 800 formulas. MANSI also has multiple cosmetics functional laboratories such as formula R&D laboratories, anti-corrosion challenge laboratories, cosmetics stability inspection laboratories, packaging
material compatibility testing laboratories, cosmetics in-vitro test laboratories, human body efficacy laboratories etc.
MANSI R&D team always follows customer-centric principle with sincere and efficient service attitude. MANSI is committed to developing high-quality, cost-effective cosmetics that satisfy customers
Human Body Efficacy Experimental
Cosmetic Efficacy Laboratories have human body efficacy evaluation, human body safety evaluation, in-vitro efficacy detection and so on with VISIA, Multi-Probe Skin Elasticity Tester (MPA580), VC20 and other professional imported equipment. The test capabilities cover human body efficacy evaluation test, consumer use test, laboratory tests, human body safety evaluation and other fields.
Certificates
Quality Management System Certification ISO9001 & ISO13485
Cosmetics Production Certification ISO22716
US GMPC Certification FDA TFDA
